Cdk5 gene expression is stimulated by Npas4

Stable Identifier
R-MMU-9634923
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
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PNG
Low
Medium
High
 | PPTX  | SBGN
Cdk5 gene expression is stimulated by Npas4
In mouse neurons treated with a differentiation medium Npas4 directly stimulates Cdk5 gene expression (Yun et al. 2013). In primary cultures of rat neurons, Cdk5 gene expression was not significantly changed upon Npas4 activation (Brigidi et al. 2019).
Literature References
PubMed ID Title Journal Year
23172225 Neuronal Per Arnt Sim (PAS) domain protein 4 (NPAS4) regulates neurite outgrowth and phosphorylation of synapsin I

Yun, J, Greenberg, ME, Kaibuchi, K, Kuroda, K, Furukawa-Hibi, Y, Nagai, T, Yamada, K

J. Biol. Chem. 2013
Participants
Input
Output
This event is regulated
Positively by
Regulator
(Npas4:Arntl,Npas4:Arnt,Npas4:Arnt2):Cdk5 gene [nucleoplasm] (Mus musculus)
Active Unit
(Npas4:Arntl,Npas4:Arnt,Npas4:Arnt2) [nucleoplasm]
Orthologous Events
CDK5 gene expression is stimulated by NPAS4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2019-01-16)
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