Reactome | Rpl11 [cytosol]

Rpl11 [cytosol]

Stable Identifier

R-MMU-9633593

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

60S ribosomal protein L11, RL11_MOUSE

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl11 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl11 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl11 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl11 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl11 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl11 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl11 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl11 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl11 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl11 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CXW4 Rpl11

Gene Names

Rpl11

Chain

initiator methionine:1, chain:2-178

Reference Genes

BioGPS Gene:67025 Rpl11

KEGG:mmu:67025 Rpl11

Monarch:67025 Rpl11

NCBI Gene:67025 Rpl11

UCSC:Q9CXW4 Rpl11

Reference Transcript

RefSeq:NM_025919.3 Rpl11

Other Identifiers

10451301

10454097

10502745

10517457

10528544

10594142

1417615_a_at

1448773_at

17431546

4344355

4383034

4423491

4464564

4555017

4559435

4564567

4574479

4598264

4746314

4953537

5005518

5067131

5203829

5236792

5385700

5452871

5457817

5526080

5536962

5540331

5588762

67025

A_51_P394524

A_52_P566208

A_55_P2139673

A_55_P2731281

GE41009

GO:0000027

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0006605

GO:0008097

GO:0010628

GO:0019843

GO:0022625

GO:0022626

GO:0031625

GO:0032435

GO:0032991

GO:0034504

GO:0042273

GO:0050821

GO:0065003

GO:0098772

GO:1901796

GO:1901798

GO:1990904

GO:1990948

GO:2000059

GO:2000435

ILMN_2665229

mMC026233

Participates

as a component of

Inferred From

RPL11 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_080195.1

ENSEMBL

ENSMUSP00000099595, ENSMUSG00000059291, ENSMUST00000102536

PRO

Q9CXW4

GlyGen

Q9CXW4

MGI

1914275

PDB

7CPU, 7LS1, 6SWA, 7LS2, 7CPV

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23804 Mdm2	12	phospho-p-S166,S188-MDM2 [nucleoplasm] (R-MMU-6793669) phospho-p-S166,S188-MDM2 [cytosol] (R-MMU-198638) MDM2 [cytosol] (R-MMU-198644) MDM2 [nucleoplasm] (R-MMU-69486) phospho-PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-MMU-6795669) phospho-p-S166,S188,T218-MDM2 [nucleoplasm] (R-MMU-6792862) phospho-p-5S,T-MDM2 [nucleoplasm] (R-MMU-6804954) MDM2 [endocytic vesicle membrane] (R-MMU-416849) MDM2 [plasma membrane] (R-MMU-416843) Mdm2 [cytosol] (R-MMU-9769903) monoSUMO1-K182-MDM2 [nucleoplasm] (R-MMU-3000408) PolyUb-MDM2 [nucleoplasm] (R-MMU-6782472)	0.723	4

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