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Mdm2 [nucleoplasm]
Stable Identifier
R-MMU-3000408
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
monoSUMO1-K182-MDM2, P23804
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
SUMOylation (Mus musculus)
SUMO E3 ligases SUMOylate target proteins (Mus musculus)
SUMOylation of ubiquitinylation proteins (Mus musculus)
PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Mus musculus)
Mdm2 [nucleoplasm] (Mus musculus)
RANBP2 SUMOylates MDM2 with SUMO1 (Mus musculus)
Mdm2 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:P23804 Mdm2
Gene Names
Mdm2
Chain
chain:1-489
Reference Genes
BioGPS Gene:17246 Mdm2
ENSEMBL:ENSMUSG00000020184.16 Mdm2
Monarch:17246 Mdm2
NCBI Gene:17246 Mdm2
UCSC:P23804 Mdm2
Reference Transcript
RefSeq:NM_010786.4 Mdm2
RefSeq:NM_001288586.2 Mdm2
Other Identifiers
10372668
134102_at
1423605_a_at
1427718_a_at
17245248
17246
4349787
4361915
4390865
4443464
4512150
4645625
4655546
4715120
4939417
5064302
5140978
5162104
5244241
5295585
5467284
5580349
5584597
98110_at
A_51_P201346
A_52_P469842
A_55_P1975475
A_55_P2606086
GE35731
GO:0000122
GO:0000278
GO:0001568
GO:0001974
GO:0002027
GO:0002039
GO:0003013
GO:0003170
GO:0003181
GO:0003203
GO:0003281
GO:0003283
GO:0003723
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006511
GO:0006886
GO:0006913
GO:0006915
GO:0006977
GO:0007089
GO:0007507
GO:0008097
GO:0008270
GO:0009410
GO:0009636
GO:0010039
GO:0010468
GO:0010628
GO:0010629
GO:0010955
GO:0010977
GO:0012501
GO:0016567
GO:0016604
GO:0016740
GO:0016874
GO:0017053
GO:0019789
GO:0019899
GO:0019904
GO:0023052
GO:0030154
GO:0030163
GO:0031625
GO:0031648
GO:0032026
GO:0032436
GO:0032991
GO:0033612
GO:0034504
GO:0036211
GO:0042176
GO:0042220
GO:0042802
GO:0042975
GO:0043021
GO:0043066
GO:0043130
GO:0043226
GO:0043518
GO:0045184
GO:0045472
GO:0045787
GO:0045892
GO:0045931
GO:0046677
GO:0046827
GO:0046872
GO:0048545
GO:0048856
GO:0048870
GO:0051149
GO:0051603
GO:0051604
GO:0051726
GO:0051865
GO:0060411
GO:0061630
GO:0061663
GO:0065003
GO:0065008
GO:0070301
GO:0071236
GO:0071301
GO:0071310
GO:0071312
GO:0071363
GO:0071375
GO:0071391
GO:0071407
GO:0071456
GO:0071480
GO:0071494
GO:0072537
GO:0072717
GO:0097718
GO:0140096
GO:1901797
GO:1902254
GO:1904404
GO:1904707
GO:1904754
GO:1990000
GO:1990785
ILMN_1229882
ILMN_1250774
ILMN_2850753
Msa.1904.0_s_at
aa415488_rc_at
aa415488_rc_g_at
mMC002697
Participates
as an output of
PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Mus musculus)
RANBP2 SUMOylates MDM2 with SUMO1 (Mus musculus)
Other forms of this molecule
Mdm2 [nucleoplasm]
Mdm2 [cytosol]
phospho-Mdm2 [nucleoplasm]
Mdm2 [plasma membrane]
Mdm2 [endocytic vesicle membrane]
phospho-Mdm2 [nucleoplasm]
phospho-Mdm2 [nucleoplasm]
Mdm2 [nucleoplasm]
Mdm2 [cytosol]
phospho-Mdm2 [cytosol]
phospho-Mdm2 [nucleoplasm]
Inferred From
monoSUMO1-K182-MDM2 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 182 (in Homo sapiens)
Coordinate
182
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_034916.1
,
NP_001275515.1
IntEnz
2.3.2.27
Ensembl
ENSMUSP00000020408
,
ENSMUST00000105263
,
ENSMUSG00000020184
,
ENSMUSP00000100898
,
ENSMUST00000020408
PRO
P23804
MGI
96952
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02340 Tp53
20
TP53 [cytosol]
(R-MMU-8869337)
PolyUb-TP53 [nucleoplasm]
(R-MMU-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-MMU-2997661)
p- S18-Tp53 [nucleoplasm]
(R-MMU-9816424)
phospho-Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-6805656)
phospho-Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-6805631)
phospho-Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-5628868)
Me2-K373-TP53 [nucleoplasm]
(R-MMU-6805759)
phospho-MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-3222226)
phospho-p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-MMU-6804378)
phospho-Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-3222124)
phospho-Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-6805719)
phospho-p-S392-TP53 [nucleoplasm]
(R-MMU-9836341)
phospho-PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-6804446)
phospho-p-S15,S33,S46-TP53 [nucleoplasm]
(R-MMU-6805268)
phospho-p-S15,S392-TP53 [nucleoplasm]
(R-MMU-3222015)
phospho-p-T55-TP53 [nucleoplasm]
(R-MMU-6805400)
phospho-p-S15,S20,S392-TP53 [nucleoplasm]
(R-MMU-6805053)
phospho-p-S15,S20-TP53 [nucleoplasm]
(R-MMU-69683)
phospho-p-S15-TP53 [nucleoplasm]
(R-MMU-69507)
0.918
9
UniProt:Q9CXW4 Rpl11
1
Rpl11 [cytosol]
(R-MMU-9633593)
0.723
4
UniProt:P47962 Rpl5
1
Rpl5 [cytosol]
(R-MMU-9633557)
0.669
3
UniProt:P62991 UBIQ
0.589
2
UniProt:O35618
5
Mdm4 [nucleoplasm]
(R-MMU-6782502)
phospho-Mdm4 [nucleoplasm]
(R-MMU-349461)
phospho-Mdm4 [nucleoplasm]
(R-MMU-6804938)
phospho-Mdm4 [nucleoplasm]
(R-MMU-349441)
Mdm4 [nucleoplasm]
(R-MMU-349430)
0.564
2
UniProt:Q5EBH1 RASF5
0.557
3
UniProt:O88904
1
HIPK1 [nucleoplasm]
(R-MMU-3215224)
0.537
3
UniProt:P62830 Rpl23
1
Rpl23 [cytosol]
(R-MMU-9633465)
0.499
2
UniProt:Q62108 Dlg4
3
SAP-90 [plasma membrane]
(R-MMU-443606)
Dlg4 [endocytic vesicle membrane]
(R-MMU-416847)
Dlg4 [cytosol]
(R-MMU-6794267)
0.463
3
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