Trim63 gene expression is activated by Foxo1 and Nr3c1

Stable Identifier
R-MMU-9625730
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Trim63 gene expression is activated by Foxo1 and Nr3c1
Recombinant mouse Foxo1 and recombinant mouse glucocorticoid receptor (Nr3c1) directly activate transcription of the Trim63 gene, acting synergistically. Trim63 (MuRF1) is an E3 ubiquitin ligase involved in degradation of muscle proteins (Waddell et al. 2008).
Literature References
PubMed ID Title Journal Year
18612045 The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene

Waddell, DS, Baehr, LM, van den Brandt, J, Johnsen, SA, Reichardt, HM, Furlow, JD, Bodine, SC

Am. J. Physiol. Endocrinol. Metab. 2008
Participants
Input
Output
This event is regulated
Positively by
Regulator
Foxo1:Nr3c1:(ALDO1,11DCORST,CORST,CORT) dimer:Trim63 gene [nucleoplasm] (Mus musculus)
Active Unit
Foxo1 [nucleoplasm]
Nr3c1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
Orthologous Events
TRIM63 gene expression is stimulated by FOXO1 and FOXO3 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-23)
Reviewed
Donlon, T  (2018-10-23)
Created
Orlic-Milacic, M  (2018-10-22)
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