Foxo1:Ppargc1a binds Pck1 gene promoter

Stable Identifier
R-MMU-9623284
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Foxo1:Ppargc1a binds Pck1 gene promoter
In mouse liver cells, Foxo1 and Pparcg1a, which form a complex, bind the promoter of the Pck1 gene, encoding Phosphoenolpyruvate carboxykinase, an enzyme involved in gluconeogenesis. Binding of Foxo1 and Pparcg1a to the Pck1 gene promoter is inhibited by insulin (Puigserver et al. 2003).
Literature References
PubMed ID Title Journal Year
12754525 Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

Walkey, CJ, Spiegelman, BM, Dong, H, Puigserver, P, Accili, D, Oriente, F, Rhee, J, Altomonte, J, Yoon, JC, Donovan, J, Kitamura, Y

Nature 2003
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Insulin [extracellular region] (Mus musculus)
Orthologous Events
FOXO1:PPARGC1A,FOXO4 binds PCK1 gene promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-10-03)
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