FOXO1:PPARGC1A,FOXO4 binds PCK1 gene promoter

Stable Identifier
R-HSA-9623281
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Based on studies in mice, FOXO1, in complex with PPARGC1A (PGC-1alpha), binds the promoter of the PCK1 gene, encoding Phosphoenolpyruvate carboxykinase, an enzyme in the gluconeogenesis pathway. Interaction of FOXO1 with PPARGC1A is inhibited by AKT-mediated phosphorylation of FOXO1, and binding of FOXO1 and PPARGC1A to the PKC1 promoter is inhibited by insulin (Puigserver et al. 2003).
FOXO3 (Hall et al. 2000) and FOXO4 (Yang et al. 2002) also bind the promoter of the PCK1 gene.

Literature References
PubMed ID Title Journal Year
11779849 An mRNA splice variant of the AFX gene with altered transcriptional activity

Yang, Z, Whelan, J, Babb, R, Bowen, BR

J. Biol. Chem. 2002
10913147 Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins

Hall, RK, Yamasaki, T, Kucera, T, Waltner-Law, M, O'Brien, R, Granner, DK

J. Biol. Chem. 2000
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