Pck1 gene expression is stimulated by Foxo1:Ppargc1a

Stable Identifier
R-MMU-9623283
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Pck1 gene expression is stimulated by Foxo1:Ppargc1a
In the mouse liver, Foxo1 and Ppargc1a (Pgc-1alpha) directly stimulate transcription of the Pck1 gene, encoding a gluconeogenesis enzyme Phosphoenolpyruvate carboxykinase (Puigserver et al. 2003).
Literature References
PubMed ID Title Journal Year
12754525 Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

Puigserver, P, Rhee, J, Donovan, J, Walkey, CJ, Yoon, JC, Oriente, F, Kitamura, Y, Altomonte, J, Dong, H, Accili, D, Spiegelman, BM

Nature 2003
Participants
Input
Output
This event is regulated
Positively by
Regulator
Foxo1:Ppargc1a:Pck1 gene [nucleoplasm] (Mus musculus)
Active Unit
Foxo1:Ppargc1a [nucleoplasm]
Orthologous Events
PCK1 gene expression is stimulated by FOXO1:PPARGC1A (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Donlon, T  (2018-10-17)
Bertaggia, E  (2018-10-26)
Created
Orlic-Milacic, M  (2018-10-03)
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