PCK1 gene expression is stimulated by FOXO1:PPARGC1A

Stable Identifier
R-HSA-9623280
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PCK1 gene expression is stimulated by FOXO1:PPARGC1A
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Based on studies in mice, FOXO1 and PPARGC1A (PGC-1alpha) directly stimulate transcription of the PCK1 gene, encoding a gluconeogenesis enzyme Phosphoenolpyruvate carboxykinase (Puigserver et al. 2003).
FOXO3 (Hall et al. 2000) and FOXO4 (Yang et al. 2002) also directly stimulates PCK1 gene transcription .
Literature References
PubMed ID Title Journal Year
10913147 Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins

Hall, RK, Yamasaki, T, Kucera, T, Waltner-Law, M, O'Brien, R, Granner, DK

J. Biol. Chem. 2000
11779849 An mRNA splice variant of the AFX gene with altered transcriptional activity

Yang, Z, Whelan, J, Babb, R, Bowen, BR

J. Biol. Chem. 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXO1:PPARGC1A,FOXO3,FOXO4:PCK1 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO1:PPARGC1A [nucleoplasm]
Inferred From
Pck1 gene expression is stimulated by Foxo1:Ppargc1a (Mus musculus)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Donlon, T  (2018-10-17)
Bertaggia, E  (2018-10-26)
Created
Orlic-Milacic, M  (2018-10-03)
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