PCK1 gene expression is stimulated by FOXO1:PPARGC1A

Stable Identifier
R-HSA-9623280
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PCK1 gene expression is stimulated by FOXO1:PPARGC1A
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Based on studies in mice, FOXO1 and PPARGC1A (PGC-1alpha) directly stimulate transcription of the PCK1 gene, encoding a gluconeogenesis enzyme Phosphoenolpyruvate carboxykinase (Puigserver et al. 2003).
FOXO3 (Hall et al. 2000) and FOXO4 (Yang et al. 2002) also directly stimulates PCK1 gene transcription .
Literature References
PubMed ID Title Journal Year
10913147 Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins

Waltner-Law, M, Kucera, T, Granner, DK, Hall, RK, Yamasaki, T, O'Brien, R

J. Biol. Chem. 2000
11779849 An mRNA splice variant of the AFX gene with altered transcriptional activity

Bowen, BR, Whelan, J, Babb, R, Yang, Z

J. Biol. Chem. 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXO1:PPARGC1A,FOXO3,FOXO4:PCK1 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO1:PPARGC1A [nucleoplasm]
Inferred From
Pck1 gene expression is stimulated by Foxo1:Ppargc1a (Mus musculus)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-10-03)
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