Foxo6 binds G6pc gene promoter

Stable Identifier
R-MMU-9623187
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Foxo6 binds G6pc gene promoter
In fasted mouse liver cells, endogenous Foxo6 binds the promoter of the G6pc gene, encoding Glucose-6-phosphatase. Binding of Foxo6 to the G6pc gene promoter is negatively regulated by insulin (Ayala et al. 2011).
Literature References
PubMed ID Title Journal Year
10480625 Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence

Ayala, JE, Streeper, RS, Desgrosellier, JS, Durham, SK, Suwanichkul, A, Svitek, CA, Goldman, JK, Barr, FG, Powell, DR, O'Brien, RM

Diabetes 1999
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Insulin [extracellular region] (Mus musculus)
Orthologous Events
FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Donlon, T  (2018-10-17)
Bertaggia, E  (2018-10-26)
Created
Orlic-Milacic, M  (2018-10-03)
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