FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter

Stable Identifier
R-HSA-9623168
Type
Reaction [binding]
Species
Homo sapiens
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FOXO1 (Ayala et al. 1999, Onuma et al. 2006, Puigserver et al. 2003), FOXO3 (Onuma et al. 2006), FOXO4 (Yang et al. 2002) and FOXO6 (Kim et al. 2011) bind insulin response elements in the promoter of the G6PC gene, encoding Glucose-6-phosphatase. Formation of the complex between FOXO1 and PPARGC1A (PGC-1alpha) may be required for FOXO1 to bind the G6PC gene promoter (Puigserver et al. 2003). Binding of FOXO transcription factors to the G6PC gene promoter is negatively regulated by insulin.

Literature References
PubMed ID Title Journal Year
11779849 An mRNA splice variant of the AFX gene with altered transcriptional activity

Yang, Z, Whelan, J, Babb, R, Bowen, BR

J. Biol. Chem. 2002
16840535 Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin

Onuma, H, Vander Kooi, BT, Boustead, JN, Oeser, JK, O'Brien, RM

Mol. Endocrinol. 2006
10480625 Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence

Ayala, JE, Streeper, RS, Desgrosellier, JS, Durham, SK, Suwanichkul, A, Svitek, CA, Goldman, JK, Barr, FG, Powell, DR, O'Brien, RM

Diabetes 1999
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