Reactome | FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter

FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter

Stable Identifier

R-HSA-9623168

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter

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FOXO1 (Ayala et al. 1999, Onuma et al. 2006, Puigserver et al. 2003), FOXO3 (Onuma et al. 2006), FOXO4 (Yang et al. 2002) and FOXO6 (Kim et al. 2011) bind insulin response elements in the promoter of the G6PC gene, encoding Glucose-6-phosphatase. Formation of the complex between FOXO1 and PPARGC1A (PGC-1alpha) may be required for FOXO1 to bind the G6PC gene promoter (Puigserver et al. 2003). Binding of FOXO transcription factors to the G6PC gene promoter is negatively regulated by insulin.

Literature References

PubMed ID	Title	Journal	Year
16840535	Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin Boustead, JN, Vander Kooi, BT, Oeser, JK, Onuma, H, O'Brien, RM	Mol. Endocrinol.	2006
11779849	An mRNA splice variant of the AFX gene with altered transcriptional activity Bowen, BR, Whelan, J, Babb, R, Yang, Z	J. Biol. Chem.	2002
10480625	Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence Powell, DR, Barr, FG, Suwanichkul, A, Streeper, RS, Svitek, CA, Durham, SK, Desgrosellier, JS, Goldman, JK, Ayala, JE, O'Brien, RM	Diabetes	1999