Crebbp binds SOH-C477-Foxo4

Stable Identifier
R-MMU-9617711
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Crebbp binds SOH-C477-Foxo4
After oxidation of recombinant mouse Foxo4 cysteine residues by reactive oxygen species (ROS), Foxo4 forms a complex with a recombinant mouse protein acetyltransferase Crebbp (Cbp). A covalent disulfide bond between Foxo4 and Crebbp facilitates complex formation (Dansen et al. 2009).
Literature References
PubMed ID Title Journal Year
19648934 Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

Dansen, TB, Smits, LM, van Triest, MH, de Keizer, PL, van Leenen, D, Koerkamp, MG, Szypowska, A, Meppelink, A, Brenkman, AB, Yodoi, J, Holstege, FC, Burgering, BM

Nat. Chem. Biol. 2009
Participants
Input
Output
Orthologous Events
EP300,CREBBP bind SOH-C481-FOXO4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Donlon, T  (2018-10-17)
Bertaggia, E  (2018-10-26)
Created
Orlic-Milacic, M  (2018-08-30)
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