ROS oxidize Foxo4 cysteine residues

Stable Identifier
R-MMU-9617657
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ROS oxidize Foxo4 cysteine residues
Reactive oxygen species (ROS) oxidize cysteine residue(s) of mouse Foxo4. There are five cysteine residues in Foxo4. Oxidation of C477 of Foxo4 has the most significant functional implications (Dansen et al. 2009).
Literature References
PubMed ID Title Journal Year
19648934 Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

Dansen, TB, Smits, LM, van Triest, MH, de Keizer, PL, van Leenen, D, Koerkamp, MG, Szypowska, A, Meppelink, A, Brenkman, AB, Yodoi, J, Holstege, FC, Burgering, BM

Nat. Chem. Biol. 2009
Participants
Input
Output
Orthologous Events
ROS oxidize FOXO4 cysteine residues (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Donlon, T  (2018-10-17)
Bertaggia, E  (2018-10-26)
Created
Orlic-Milacic, M  (2018-08-30)
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