Inhibition of Rig-I signaling by Atg5-Atg12 conjugate

Stable Identifier
R-MMU-936387
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Inhibition of Rig-I signaling by Atg5-Atg12 conjugate
Autophagy protein 5 (ATG5) and autophagy-related protein 12 (ATG12) conjugate negatively regulates the type I IFN production pathway by directly associating with DDX58/IFIH1 and MAVS through the caspase recruitment domains (CARDs). The ATG5-ATG12 conjugate intercalates between the CARDs of DDX58/IFIH1 and MAVS and inhibits signal transmission, resulting in suppression of type I IFN production and innate antiviral immune responses.
Literature References
PubMed ID Title Journal Year
17709747 The Atg5 Atg12 conjugate associates with innate antiviral immune responses

Jounai, N, Takeshita, F, Kobiyama, K, Sawano, A, Miyawaki, A, Xin, KQ, Ishii, KJ, Kawai, T, Akira, S, Suzuki, K, Okuda, K

Proc Natl Acad Sci U S A 2007
Participants
Input
Output
Orthologous Events
Inhibition of MDA5-IPS1 signaling by Atg5-Atg12 conjugate (Gallus gallus)
Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)
Authored
Garapati, P V  (2010-08-23)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Created
Garapati, P V  (2010-08-23)
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