Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS

Stable Identifier
R-HSA-936378
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
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Autophagy protein 5 (ATG5) and autophagy-related protein 12 (ATG12) conjugate negatively regulates the type I IFN production pathway by directly associating with DDX58/IFIH1 and MAVS through the caspase recruitment domains (CARDs). The ATG5-ATG12 conjugate intercalates between the CARDs of DDX58/IFIH1 and MAVS and inhibits signal transmission, resulting in suppression of type I IFN production and innate antiviral immune responses.

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