Reactome | Atp6v1g3 [cytosol]

Atp6v1g3 [cytosol]

Stable Identifier

R-MMU-912589

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

ATP6V1G3, Q8BMC1

Locations in the PathwayBrowser

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Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to starvation (Mus musculus)
    - Amino acids regulate mTORC1 (Mus musculus)
      - RRAGA,B exchanges GDP for GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
      - RRAGA,B hydrolyzes GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
      - RRAGC,D exchanges GTP for GDP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
      - RRAGC,D hydrolyzes GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
      - mTORC1 binds RHEB:GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - ROS and RNS production in phagocytes (Mus musculus)
    - Intraphagosomal pH is lowered to 5 by V-ATPase (Mus musculus)
      - V-ATPase [phagocytic vesicle membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by Insulin receptor (Mus musculus)
    - Insulin receptor recycling (Mus musculus)
      - ATP6AP1 binds V-ATPase (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
      - Endosome acidification (Mus musculus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)

Transport of small molecules (Mus musculus)

- Ion channel transport (Mus musculus)
  - ATP6AP1 binds V-ATPase (Mus musculus)
    - V-ATPase [endosome membrane] (Mus musculus)
      - ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
    - V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
      - V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
- Iron uptake and transport (Mus musculus)
  - Transferrin endocytosis and recycling (Mus musculus)
    - ATP6AP1 binds V-ATPase (Mus musculus)
      - V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)
    - Acidification of Tf:TfR1 containing endosome (Mus musculus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1G dimer [cytosol] (Mus musculus)
        
        ATP6V1G [cytosol] (Mus musculus)
        
        Atp6v1g3 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8BMC1

Gene Names

Atp6v1g3

Reference Genes

BioGPS Gene:338375 Atp6v1g3

ENSEMBL:ENSMUSG00000026394

KEGG:mmu:338375 Atp6v1g3

Monarch:338375 Atp6v1g3

NCBI Gene:338375 Atp6v1g3

UCSC:Q8BMC1 Atp6v1g3

Reference Transcript

RefSeq:NM_177397.3 Atp6v1g3

Other Identifiers

10350343

115650_at

17217848

338375

4501600

4503438

4753939

5236757

5444118

5574284

A_51_P514267

A_52_P421082

A_55_P2145759

GO:0000221

GO:0005829

GO:0005886

GO:0006811

GO:0016020

GO:0016471

GO:0016787

GO:0016887

GO:0030672

GO:0046961

GO:0051117

GO:0055085

GO:0097401

GO:1902600

ILMN_2683356

mMC012391

Participates

as a member of

ATP6V1G [cytosol] (Mus musculus)

Inferred From

ATP6V1G3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_796371.1

ENSEMBL

ENSMUSP00000027643, ENSMUSG00000026394, ENSMUST00000027643

PRO

Q8BMC1

MGI

2450548

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