Jak2 phosphorylates Vav1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1

Stable Identifier
R-MMU-9029162
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Jak2 phosphorylates Vav1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1
Phosphorylated Jak2 phosphorylates Vav1 bound to Grb2 in a large complex assembled on the phosphorylated Epor (Miura et al. 1994). Phosphorylation of Vav1 activates its guanine nucleotide exchange activity (Crespo et al. 1997).
Literature References
PubMed ID Title Journal Year
8990121 Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Crespo, P, Schuebel, KE, Ostrom, AA, Gutkind, JS, Bustelo, XR

Nature 1997
7527668 Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor

Miura, O, Miura, Y, Nakamura, N, Quelle, FW, Witthuhn, BA, Ihle, JN, Aoki, N

Blood 1994
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1 [plasma membrane]

Physical Entity
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1 [plasma membrane] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 (Homo sapiens)
Authored
May, B  (2017-11-11)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-11-14)
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