Jak2 phosphorylates Vav1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1

Stable Identifier
R-MMU-9029162
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Jak2 phosphorylates Vav1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1
Phosphorylated Jak2 phosphorylates Vav1 bound to Grb2 in a large complex assembled on the phosphorylated Epor (Miura et al. 1994). Phosphorylation of Vav1 activates its guanine nucleotide exchange activity (Crespo et al. 1997).
Literature References
PubMed ID Title Journal Year
8990121 Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Ostrom, AA, Bustelo, XR, Gutkind, JS, Crespo, P, Schuebel, KE

Nature 1997
7527668 Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor

Ihle, JN, Miura, Y, Witthuhn, BA, Miura, O, Quelle, FW, Aoki, N, Nakamura, N

Blood 1994
Participants
Catalyst Activity

protein tyrosine kinase activity of Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1 [plasma membrane]

Orthologous Events
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