JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1

Stable Identifier
R-HSA-9029151
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylated JAK2 phosphorylates VAV1 bound to GRB2 in a large complex assembled on the phosphorylated EPOR (Odai et al. 1997, Shigematsu et al. 1997). Phosphorylation of VAV1 activates its guanine nucleotide exchange activity (inferred from the mouse homolog).

Literature References
PubMed ID Title Journal Year
9162069 Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity

Shigematsu, H, Iwasaki, H, Otsuka, T, Ohno, Y, Arima, F, Niho, Y

J. Biol. Chem. 1997
9209406 The signal transduction through Grb2/Ash in hematopoietic cells

Odai, H, Hanazono, Y, Sasaki, K, Iwamatu, A, Yazaki, Y, Hirai, H

Leukemia 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created