Jak2 phosphorylates Shc1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef:Shc1

Stable Identifier
R-MMU-9029147
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Jak2 phosphorylates Shc1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef:Shc1
Phosphorylated Jak2 associated with the Epor complex phosphorylates Shc1 bound to Crkl in the Epor complex (Damen et al. 1993, Miura et al. 1994, Zochodne et al. 2000). Shc1 may also bind Jak2 directly (He et al. 1995). The phosphorylated Shc1 serves as a scaffold to bind downstream effectors including Grb2:Vav1 and Grb2:Sos1 (Miura et al. 1994).
Literature References
PubMed ID Title Journal Year
8400282 Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

Damen, JE, Liu, L, Cutler, RL, Krystal, G

Blood 1993
7961995 Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor

Miura, Y, Miura, O, Ihle, JN, Aoki, N

J. Biol. Chem. 1994
10822380 Epo regulates erythroid proliferation and differentiation through distinct signaling pathways: implication for erythropoiesis and Friend virus-induced erythroleukemia

Zochodne, B, Truong, AH, Stetler, K, Higgins, RR, Howard, J, Dumont, D, Berger, SA, Ben-David, Y

Oncogene 2000
7538110 Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway

He, TC, Jiang, N, Zhuang, H, Wojchowski, DM

J. Biol. Chem. 1995
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:Shc1 [plasma membrane]

Physical Entity
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:Shc1 [plasma membrane] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 (Homo sapiens)
Authored
May, B  (2017-11-11)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-11-14)
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