JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1

Stable Identifier
R-HSA-9029155
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
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Phosphorylated JAK2 associated with the EPOR complex phosphorylates SHC1 (Damen et al. 1993, Verma et al. 2014) bound to CRKL in the EPOR complex. The phosphorylated SHC1 serves as a scaffold to bind downstream effectors including GRB2:VAV1 and GRB2:SOS1.
Literature References
PubMed ID Title Journal Year
8400282 Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

Cutler, RL, Liu, L, Krystal, G, Damen, JE

Blood 1993
25092874 RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development

Stokes, MP, Verma, R, Schatz, PJ, Leu, K, Wojchowski, DM, Young, PR, Su, S, McCrann, DJ, Silva, JC, Green, JM

J. Exp. Med. 2014
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:SHC1 [plasma membrane]

Physical Entity
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:SHC1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Jak2 phosphorylates Shc1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef:Shc1 (Mus musculus)
Authored
May, B  (2017-11-11)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-11-14)
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