JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1

Stable Identifier
R-HSA-9029155
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylated JAK2 associated with the EPOR complex phosphorylates SHC1 (Damen et al. 1993, Verma et al. 2014) bound to CRKL in the EPOR complex. The phosphorylated SHC1 serves as a scaffold to bind downstream effectors including GRB2:VAV1 and GRB2:SOS1.

Literature References
PubMed ID Title Journal Year
25092874 RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development

Verma, R, Su, S, McCrann, DJ, Green, JM, Leu, K, Young, PR, Schatz, PJ, Silva, JC, Stokes, MP, Wojchowski, DM

J. Exp. Med. 2014
8400282 Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

Damen, JE, Liu, L, Cutler, RL, Krystal, G

Blood 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:SHC1 [plasma membrane]
Physical Entity
Activity
Inferred From
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