Lyn phosphorylates Plcg1,2 in Epo:phospho-Epor:phospho-Jak2:Lyn:Irs2:Plcg1,2

Stable Identifier
R-MMU-9027429
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Lyn phosphorylates Plcg1,2 in Epo:phospho-Epor:phospho-Jak2:Lyn:Irs2:Plcg1,2
Plcg1 (Phospholipase C gamma1) or Plcg2 bound to the activated Epor is phosphorylated on tyrosine residues (Mason-Garcia et al. 1992, Boudot et al. 1999, Boudot et al. 2002, Tong et al. 2004, Halupa et al. 2005, Schnoder et al. 2015) by the kinase LYN (Boudot et al. 2003).
Literature References
PubMed ID Title Journal Year
12504103 Involvement of the Src kinase Lyn in phospholipase C-gamma 2 phosphorylation and phosphatidylinositol 3-kinase activation in Epo signalling

Boudot, C, Dassé, E, Lambert, E, Kadri, Z, Mayeux, P, Chrétien, S, Haye, B, Billat, C, Petitfrère, E

Biochem. Biophys. Res. Commun. 2003
15953601 Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma

Halupa, A, Chohan, M, Stickle, NH, Beattie, BK, Miller, BA, Barber, DL

Exp. Cell Res. 2005
1317100 Signal transduction by the erythropoietin receptor: evidence for the activation of phospholipases A2 and C

Mason-Garcia, M, Clejan, S, Tou, JS, Beckman, BS

Am. J. Physiol. 1992
25394487 Epo-induced erythroid maturation is dependent on Plcγ1 signaling

Schnöder, TM, Arreba-Tutusaus, P, Griehl, I, Bullinger, L, Buschbeck, M, Lane, SW, Döhner, K, Plass, C, Lipka, DB, Heidel, FH, Fischer, T

Cell Death Differ. 2015
10567359 Erythropoietin induces glycosylphosphatidylinositol hydrolysis. Possible involvement of phospholipase c-gamma(2)

Boudot, C, Petitfrère, E, Kadri, Z, Chrétien, S, Mayeux, P, Haye, B, Billat, C

J. Biol. Chem. 1999
15329338 Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase Cgamma and IP3R

Tong, Q, Chu, X, Cheung, JY, Conrad, K, Stahl, R, Barber, DL, Mignery, G, Miller, BA

Am. J. Physiol., Cell Physiol. 2004
12135708 Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells

Boudot, C, Kadri, Z, Petitfrère, E, Lambert, E, Chrétien, S, Mayeux, P, Haye, B, Billat, C

Cell. Signal. 2002
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:Plcg1,2 [plasma membrane]

Physical Entity
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:Plcg1,2 [plasma membrane] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 (Homo sapiens)
Authored
May, B  (2017-10-30)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-11-01)
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