Translation of Robo3.2 mRNA initiates NMD

Stable Identifier
R-MMU-9014672
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
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Medium
High
 | PPTX  | SBGN
Translation of Robo3.2 mRNA initiates NMD
Mouse Robo3.2 mRNA, which contains a premature stop codon, binds to components of the nonsense mediated decay (NMD) machinery, Upf1 and Upf2, and is subject to NMD in commissural axons at the midline (the floor plate) (Colak et al. 2013).
Literature References
PubMed ID Title Journal Year
23746841 Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay

Colak, D, Ji, SJ, Porse, BT, Jaffrey, SR

Cell 2013
Participants
Input
Output
Orthologous Events
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-26)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-08-02)
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