Src phosphorylates Robo3.1 in response to Ntn1

Stable Identifier
R-MMU-9011252
Type
Reaction [omitted]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Src phosphorylates Robo3.1 in response to Ntn1
In mouse neurons, Ntn1 (netrin-1)-mediated activation of Dcc, induces Src-mediated phosphorylation of Robo3.1 on a conserved tyrosine Y1019 (Zelina et al. 2014).
Literature References
PubMed ID Title Journal Year
25433640 Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution

Zelina, P, Blockus, H, Zagar, Y, Péres, A, Friocourt, F, Wu, Z, Rama, N, Fouquet, C, Hohenester, E, Tessier-Lavigne, M, Schweitzer, J, Roest Crollius, H, Chédotal, A

Neuron 2014
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of MyrG-p-Y424-Src [plasma membrane]

Physical Entity
MyrG-p-Y424-Src [plasma membrane] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
SRC phosphorylates ROBO3.1 in response to NTN1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-26)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-06-29)
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