SRC phosphorylates ROBO3.1 in response to NTN1

Stable Identifier
R-HSA-9011241
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In response to NTN1 (netrin-1)-mediated activation of DCC, based on mouse studies, SRC phosphorylates ROBO3.1 on a conserved tyrosine Y1019. The mechanism of SRC recruitment to ROBO3.1 in response to NTN1 is not known (Zelina et al. 2014). The biological significance of SRC-mediated phosphorylation of ROBO3.1 is not known.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of MyrG-p-Y419-SRC [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created