SRC phosphorylates ROBO3.1 in response to NTN1

Stable Identifier
R-HSA-9011241
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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SRC phosphorylates ROBO3.1 in response to NTN1
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In response to NTN1 (netrin-1)-mediated activation of DCC, based on mouse studies, SRC phosphorylates ROBO3.1 on a conserved tyrosine Y1019. The mechanism of SRC recruitment to ROBO3.1 in response to NTN1 is not known (Zelina et al. 2014). The biological significance of SRC-mediated phosphorylation of ROBO3.1 is not known.
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of MyrG-p-Y419-SRC [plasma membrane]

Physical Entity
MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Src phosphorylates Robo3.1 in response to Ntn1 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-26)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-06-29)
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