Robo1 gene expression is inhibited by Lhx2

Stable Identifier
R-MMU-9011080
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
General
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PNG
Low
Medium
High
 | PPTX  | SBGN
Robo1 gene expression is inhibited by Lhx2
Mouse Lhx2, a LIM-homeodomain transcription factor, directly represses transcription of the Robo1 gene by binding to evolutionarily conserved Lhx2 binding sites about 30 kb downstream from the Robo1 gene transcription start site. Lhx2 is involved in thalamocortical axon guidance (Marcos-Mondejar et al. 2012).
Literature References
PubMed ID Title Journal Year
22457488 The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors

Carlsson, L, Li, JY, López-Bendito, G, Marcos-Mondéjar, P, Peregrín, S, Tole, S

J. Neurosci. 2012
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Lhx2:Robo1 gene [nucleoplasm] (Mus musculus)
Active Unit
Lhx2 [nucleoplasm]
Orthologous Events
ROBO1 gene expression is inhibited by LHX2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-23)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-06-29)
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