ROBO1 gene expression is inhibited by LHX2

Stable Identifier
R-HSA-9011083
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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ROBO1 gene expression is inhibited by LHX2
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Based on studies in mice, LHX2, a LIM-homeodomain transcription factor, directly represses transcription of the ROBO1 gene by binding to evolutionarily conserved LHX2 binding sites upstream of the ROBO1 gene promoter region. LHX2 is involved in thalamocortical axon guidance (Marcos-Mondejar et al. 2012). In commissural relay neurons of the dorsal spinal cord, however, ROBO1 expression is not affected by LHX2 (Wilson et al. 2008).

Transcription factors GBX2 and LMO3 may be indirectly involved in ROBO1 gene expression regulation by LHX2 (Chatterjee et al. 2012).

Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
LHX2:ROBO1 gene [nucleoplasm] (Homo sapiens)
Active Unit
LHX2 [nucleoplasm]
Inferred From
Robo1 gene expression is inhibited by Lhx2 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-23)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-06-29)
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