Proteasome degrades polyubiquitinated Runx2

Stable Identifier
R-MMU-9009438
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Proteasome degrades polyubiquitinated Runx2
Recombinant mouse Runx2, polyubiquitinated by Smurf1, is degraded by the proteasome (Zhao et al. 2003).
Literature References
PubMed ID Title Journal Year
12738770 E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation

Zhao, M, Qiao, M, Oyajobi, BO, Mundy, GR, Chen, D

J. Biol. Chem. 2003
Participants
Input
Output
Catalyst Activity

endopeptidase activity of m26S Proteasome [cytosol]

Physical Entity
m26S Proteasome [cytosol] (Mus musculus)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Proteasome degrades PolyUb-RUNX2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-17)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-17)
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