Proteasome degrades PolyUb-RUNX2

Stable Identifier
R-HSA-9009362
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
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Proteasome degrades PolyUb-RUNX2
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RUNX2 polyubiquitinated by STUB1 (CHIP) (Li et al. 2008) or SMURF1 (Zhao et al. 2003, Yang et al. 2014) is degraded by the proteasome.

Literature References
PubMed ID Title Journal Year
25260729 A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells

Yang, F, Xu, N, Li, D, Guan, L, He, Y, Zhang, Y, Lu, Q, Zhang, X

J Endod 2014
18541707 CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

Li, X, Huang, M, Zheng, H, Wang, Y, Ren, F, Shang, Y, Zhai, Y, Irwin, DM, Shi, Y, Chen, D, Chang, Z

J. Cell Biol. 2008
12738770 E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation

Zhao, M, Qiao, M, Oyajobi, BO, Mundy, GR, Chen, D

J. Biol. Chem. 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
26S proteasome [cytosol]
Activity
endopeptidase activity (0004175)
Inferred From
Proteasome degrades polyubiquitinated Runx2 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-16)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-16)