Proteasome degrades PolyUb-RUNX2

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RUNX2 polyubiquitinated by STUB1 (CHIP) (Li et al. 2008) or SMURF1 (Zhao et al. 2003, Yang et al. 2014) is degraded by the proteasome.

Literature References
PubMed ID Title Journal Year
18541707 CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

Ren, F, Shi, Y, Zhai, Y, Irwin, DM, Li, X, Chang, Z, Shang, Y, Zheng, H, Huang, M, Chen, D, Wang, Y

J. Cell Biol. 2008
25260729 A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells

Guan, L, Yang, F, Lu, Q, Zhang, Y, Li, D, Zhang, X, Xu, N, He, Y

J Endod 2014
12738770 E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation

Oyajobi, BO, Qiao, M, Zhao, M, Mundy, GR, Chen, D

J. Biol. Chem. 2003
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Inferred From
Cite Us!