Proteasome degrades polyubiquitinated Runx2

Stable Identifier
R-MMU-9008115
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Proteasome degrades polyubiquitinated Runx2
In mouse cells, polyubiquitination of Runx2 in the context of the complex of Runx2, Hivep3 (Shn3, Schnurri-3) and Wwp1, leads to proteasome-mediated degradation of Runx2 (Jones et al. 2006).
Literature References
PubMed ID Title Journal Year
16728642 Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3

Jones, DC, Wein, MN, Oukka, M, Hofstaetter, JG, Glimcher, MJ, Glimcher, LH

Science 2006
Participants
Input
Output
Catalyst Activity

endopeptidase activity of m26S Proteasome [cytosol]

Physical Entity
m26S Proteasome [cytosol] (Mus musculus)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-07)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-07)
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