Proteasome degrades polyubiquitinated RUNX2

Stable Identifier
R-HSA-9008110
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Based on studies in mice, proteasome degrades RUNX2 polyubiquitinated by WWP1 in the context of the complex of RUNX2, HIVEP3 (SHN3, Schnurri-3) and WWP1 (Jones et al. 2006).

Literature References
PubMed ID Title Journal Year
16728642 Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3

Jones, DC, Wein, MN, Oukka, M, Hofstaetter, JG, Glimcher, MJ, Glimcher, LH

Science 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created