Proteasome degrades polyubiquitinated RUNX2

Stable Identifier
R-HSA-9008110
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Proteasome degrades polyubiquitinated RUNX2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on studies in mice, proteasome degrades RUNX2 polyubiquitinated by WWP1 in the context of the complex of RUNX2, HIVEP3 (SHN3, Schnurri-3) and WWP1 (Jones et al. 2006).

Literature References
PubMed ID Title Journal Year
16728642 Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3

Glimcher, LH, Oukka, M, Wein, MN, Hofstaetter, JG, Jones, DC, Glimcher, MJ

Science 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Inferred From
Proteasome degrades polyubiquitinated Runx2 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-07)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-07)
Cite Us!