Based on studies in mice, proteasome degrades RUNX2 polyubiquitinated by WWP1 in the context of the complex of RUNX2, HIVEP3 (SHN3, Schnurri-3) and WWP1 (Jones et al. 2006).
Glimcher, LH, Oukka, M, Wein, MN, Hofstaetter, JG, Jones, DC, Glimcher, MJ
endopeptidase activity of 26S proteasome [cytosol]
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