Proteasome degrades polyubiquitinated RUNX2

Stable Identifier
R-HSA-9008110
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Proteasome degrades polyubiquitinated RUNX2
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Based on studies in mice, proteasome degrades RUNX2 polyubiquitinated by WWP1 in the context of the complex of RUNX2, HIVEP3 (SHN3, Schnurri-3) and WWP1 (Jones et al. 2006).
Literature References
PubMed ID Title Journal Year
16728642 Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3

Glimcher, LH, Oukka, M, Wein, MN, Hofstaetter, JG, Jones, DC, Glimcher, MJ

Science 2006
Participants
Input
Output
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as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Inferred From
Proteasome degrades polyubiquitinated Runx2 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-07)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-07)
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