Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2

Stable Identifier
R-MMU-9007126
Type
Reaction [omitted]
Species
Mus musculus
Compartment
Synonyms
Gab2 binds to the Il15ra:Il15:Il2rb:JAK1:Il2rg:p-Jak3:p-Y-Shc1:Grb2 complex
General
SVG |   | PPTX  | SBGN
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2

Grb2 associated binding protein 2 (Gab2) is believed to bind and be phosphorylated in response to Interleukin-2 (Il2) and Interleukin-15 (Il15) stimulation. Its phosphorylation is greatly diminished by mutation of the site in the Interleukin-2 Receptor beta chain (Y338F) (Il2rb) that recruits SHC transforming protein 1 (Shc1) (Gadina et al.2000, Wöhrle et al.2009, Gesbert et al. 1998, Brockdorff et al. 2001).
Gab2 is a phosphoprotein that is suggested to associates with PI3kinase, Growth factor receptor-bound protein 2 (Grb2) and Tyrosine protein phosphatase non-receptor type 11 (Ptpn11 or Shp2) in T and Natural Killer (NK) cells (Gu et al. 2000).
This is a black box event because Gab2 binding is inferred from Il15 stimulation of Gab2 phosphorylation (Brockdorff et al. 2001).

Literature References
PubMed ID Title Journal Year
9660791 A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes

Bertoglio, J, Guenzi, C, Gesbert, F

J. Biol. Chem. 1998
10849428 The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines

Neel, BG, Gadina, M, Gu, H, Sudarshan, C, Zhou, YJ, Visconti, R, O'Shea, JJ

J. Biol. Chem. 2000
19523893 How to Grb2 a Gab

Wöhrle, FU, Brummer, T, Daly, RJ

Structure 2009
Participants
Orthologous Events
Authored
Reviewed
Created
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