IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
GAB2 binds GRB2 from the IL15RA:IL15:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 complex
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Inferred from mouse: GRB2 associated binding protein 2 (GAB2) is believed to bind and be phosphorylated in response to Interleukin-2 (IL2) and Interleukin-15 (IL15) stimulation. Its phosphorylation is greatly diminished by mutation of the site in the Interleukin-2 Receptor beta chain (Y338F) (IL2RB, IL2Rβ) that recruits SHC transforming protein 1 (SHC1) (Gadina et al.2000, Wöhrle et al.2009, Gesbert et al. 1998, Brockdorff et al. 2001). GAB2 is a phosphoprotein that is suggested to associates with PI3kinase, Growth factor receptor-bound protein 2 (GRB2) and Tyrosine protein phosphatase non-receptor type 11 (PTPN11 or SHP2) in T and Natural Killer (NK) cells (Gu et al. 2000).This is a black box event because GAB2 binding is inferred from IL15 stimulation of GAB2 phosphorylation (Brockdorff et al. 2001). More in detail, human and mouse IL15 have 70.2% amino acid sequence similarity and exhibit similar trans-presentation mechanism, signal transduction machinery and biological activities. Similarly, human IL15 shows cross-reactivity with mouse cells and it was demonstrated that human and mouse IL15 showed similar responses in mouse models (Stoklasek et al. 2006) (Patidar et al. data not published).

Inferred From
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