Phospho-Jak2 phosphorylates Epor

Stable Identifier
R-MMU-9006327
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phospho-Jak2 phosphorylates Epor
Phosphorylated Jak2 phosphorylates 8 tyrosine residues in the cytoplasmic tail of Epor (Miura et al. 1001, Damen et al. 1992, Yoshimura and Lodish 1992, Witthuhn et al. 1993, Miura et al. 1994, Sawyer and Penta 1996, Tilbrook et al. 1996, Ueda et al. 2017). The phosphorylated residues then serve as binding sites for downstream signaling molecules such as Stat5, phospholipase C, and phosphatidylinositol 3-kinase (Sawyer and Penta 1996).
Literature References
PubMed ID Title Journal Year
1310150 In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130

Lodish, HF, Yoshimura, A

Mol. Cell. Biol. 1992
27998978 Three Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced Tumorigenesis

Funakoshi-Tago, M, Tago, K, Ueda, F, Tamura, H

J. Biol. Chem. 2017
8943308 Association of JAK2 and STAT5 with erythropoietin receptors. Role of receptor phosphorylation in erythropoietin signal transduction

Penta, K, Sawyer, ST

J. Biol. Chem. 1996
8343951 JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

Witthuhn, BA, Quelle, FW, Miura, O, Yi, T, Tang, B, Silvennoinen, O, Ihle, JN

Cell 1993
8068943 Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo

Ihle, JN, Witthuhn, BA, Miura, O, Quelle, FW, Aoki, N, Nakamura, N

Blood 1994
1656216 Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis

Ihle, JN, D'Andrea, A, Miura, O, Kabat, D

Mol. Cell. Biol. 1991
1382712 Erythropoietin-induced tyrosine phosphorylations in a high erythropoietin receptor-expressing lymphoid cell line

Hughes, P, Mui, AL, Damen, J, Humphries, K, Krystal, G

Blood 1992
9052992 Regulation of the erythropoietin receptor and involvement of JAK2 in differentiation of J2E erythroid cells

Klinken, SP, Tilbrook, PA, Bittorf, T, Ingley, E, Callus, BA, Busfield, SJ

Cell Growth Differ. 1996
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Epo:Epor:p-12Y-Jak2:Lyn:Irs2 [plasma membrane]

Physical Entity
Epo:Epor:p-12Y-Jak2:Lyn:Irs2 [plasma membrane] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phospho-JAK2 phosphorylates EPOR (Homo sapiens)
Authored
May, B  (2017-04-22)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-05-13)
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