Phospho-JAK2 phosphorylates EPOR

Stable Identifier
R-HSA-9006323
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylated JAK2 phosphorylates 8 tyrosine residues in the cytoplasmic tail of EPOR (Dusanter-Fourt et al. 1992, McGraw et al. 2012, and inferred from mouse homologs). The phosphorylated residues then serve as binding sites for scaffold proteins such as CRKL and GAB1 and downstream signaling proteins such as STAT5, phospholipase C, and phosphatidylinositol 3-kinase.

Literature References
PubMed ID Title Journal Year
22509308 Erythropoietin receptor signaling is membrane raft dependent

McGraw, KL, Fuhler, GM, Johnson, JO, Clark, JA, Caceres, GC, Sokol, L, List, AF

PLoS ONE 2012
1375226 Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells

Dusanter-Fourt, I, Casadevall, N, Lacombe, C, Muller, O, Billat, C, Fischer, S, Mayeux, P

J. Biol. Chem. 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EPO:EPOR:p-Y12-JAK2:LYN:IRS2 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created