Il15ra:Il15:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3 phosphorylates Shc1

Stable Identifier
R-MMU-8983294
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, extracellular region, plasma membrane
Synonyms
Shc1 is phosphorylated by Il15ra:Il15:Il2rb:Jak1:Il2rg:p-Jak3:Shc1
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Il15ra:Il15:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3 phosphorylates Shc1

Interleukin-15 (Il15) stimulates the phosphorylation of Shc1 bound to Interleukin-2 receptor subunit beta (Il2rb) (Zambricki et al 2005), which is a component of the Il15 and Il2 receptor complexes (Bennet et al. 1994, Li et al. 1994).

Literature References
PubMed ID Title Journal Year
10849428 The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines

Neel, BG, Gadina, M, Gu, H, Sudarshan, C, Zhou, YJ, Visconti, R, O'Shea, JJ

J. Biol. Chem. 2000
10982827 New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

Lord, JD, Moon, JJ, Neel, BG, Nelson, BH, Maeda, H, Yoakim, M, Gu, H

Mol Cell Biol 2000
Participants
Input
Output
Orthologous Events
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)
Authored
Duenas, C  (2017-08-07)
Reviewed
Patidar, M  (2017-08-07)
Created
Duenas, C  (2017-03-23)
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