Inferred from mouse: Interleukin-15 (IL15) stimulates the phosphorylation of SHC1 bound to Interleukin-2 receptor subunit beta (IL2RB, IL2Rβ) (Zambricki et al 2005), which is a component of the IL15 and IL2 receptor complexes (Bennet et al. 1994, Li et al. 1994). More in detail, human and mouse IL15 have 70.2% amino acid sequence similarity and exhibit similar trans-presentation mechanism, signal transduction machinery and biological activities. Similarly, human IL15 shows cross reactivity with mouse cells and it was demonstrated that human and mouse IL15 showed similar responses in mouse models (Stoklasek et al. 2006) (Patidar et al. data not published).