Reactome | Gnai3 [plasma membrane]

Gnai3 [plasma membrane]

Stable Identifier

R-MMU-8964312

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Guanine nucleotide-binding protein G, GNAI3_MOUSE

Locations in the PathwayBrowser

Expand all

Hemostasis (Mus musculus)

- Platelet activation, signaling and aggregation (Mus musculus)
  - Signal amplification (Mus musculus)
    - ADP signalling through P2Y purinoceptor 12 (Mus musculus)
      - Activated P2Y purinoceptor 12 binds G-protein Gi (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)
      - Dissociation of the P2Y purinoceptor 12:Gi complex (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)
      - Gi activation by P2Y purinoceptor 12 (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)

Neuronal System (Mus musculus)

- Transmission across Chemical Synapses (Mus musculus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
    - GABA receptor activation (Mus musculus)
      - GABA B receptor activation (Mus musculus)
        
        Activation of GABAB receptors (Mus musculus)
        
        Adenylate cyclase inhibitory pathway (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)
        
        Dissociation of the Gi alpha:G olf complex (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai3 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9DC51 Gnai3

Gene Names

Gnai3

Chain

initiator methionine:1, chain:2-354

Reference Genes

BioGPS Gene:14679 Gnai3

KEGG:mmu:14679 Gnai3

Monarch:14679 Gnai3

NCBI Gene:14679 Gnai3

UCSC:Q9DC51 Gnai3

Reference Transcript

RefSeq:NM_010306.3 Gnai3

Other Identifiers

10501265

107917_at

1428645_at

1437225_x_at

14679

17409217

4534760

4551666

4555133

4860330

5114830

5137767

5259149

5266003

5275005

5279100

5282361

5356071

5458493

94814_at

A_51_P237695

GE33080

GO:0000139

GO:0000166

GO:0001664

GO:0003924

GO:0005515

GO:0005525

GO:0005654

GO:0005730

GO:0005737

GO:0005789

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005834

GO:0005856

GO:0005886

GO:0007165

GO:0007186

GO:0007188

GO:0007193

GO:0016020

GO:0016239

GO:0016787

GO:0019001

GO:0019003

GO:0030496

GO:0031683

GO:0034451

GO:0036064

GO:0046039

GO:0046872

GO:0051301

GO:0055086

GO:1901135

ILMN_2733433

Msa.35014.0_f_at

aa204042_s_at

mMC018564

Participates

as a component of

G alpha (i):GTP [plasma membrane] (Mus musculus)

as a member of

G alpha (i) [plasma membrane] (Mus musculus)

Inferred From

GNAI3 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_034436.1

ENSEMBL

ENSMUST00000000001, ENSMUSG00000000001, ENSMUSP00000000001

PRO

Q9DC51

GlyGen

Q9DC51

MGI

95773

PDB

3AB3

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