Ihh gene expression is stimulated by Runx2

Stable Identifier
R-MMU-8941290
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ihh gene expression is stimulated by Runx2
Binding of mouse Runx2, presumably in complex with Cbfb, to evolutionarily conserved Runx2 binding sites in the promoter of the Ihh gene stimulates Ihh transcription. The Ihh gene encodes Indian hedgehog, which is involved in limb growth by regulating chondrocyte maturation. In mice, Runx3 is also involved in chondrocyte maturation, but it is uncertain whether this function of Runx3 is conserved in humans (Yoshida et al. 2004).
Literature References
PubMed ID Title Journal Year
15107406 Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog

Ito, Y, Fujita, T, Komori, T, Inoue, K, Takada, K, Yoshida, CA, Furuichi, T, Yamamoto, H, Zanma, A, Ito, K, Yamana, K

Genes Dev. 2004
Participants
Input
Output
This event is regulated
Positively by
Regulator
Runx2:Cbfb:Ihh gene [nucleoplasm] (Mus musculus)
Active Unit
Runx2:Cbfb [nucleoplasm]
Orthologous Events
IHH gene transcription is stimulated by RUNX2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2016-07-01)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-29)
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