IHH gene transcription is stimulated by RUNX2

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R-HSA-8878266
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Reaction [omitted]
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Homo sapiens
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Based on studies in mice, binding of RUNX2, presumably in complex with CBFB, to evolutionarily conserved RUNX2 response elements in the promoter of the IHH gene stimulates IHH transcription. The IHH gene encodes Indian hedgehog, which controls limb growth by regulating chondrocyte proliferation and maturation (Yoshida et al. 2004).

Literature References
PubMed ID Title Journal Year
15107406 Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog

Yoshida, CA, Yamamoto, H, Fujita, T, Furuichi, T, Ito, K, Inoue, K, Yamana, K, Zanma, A, Takada, K, Ito, Y, Komori, T

Genes Dev. 2004
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