IHH gene transcription is stimulated by RUNX2

Stable Identifier
R-HSA-8878266
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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IHH gene transcription is stimulated by RUNX2
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Based on studies in mice, binding of RUNX2, presumably in complex with CBFB, to evolutionarily conserved RUNX2 response elements in the promoter of the IHH gene stimulates IHH transcription. The IHH gene encodes Indian hedgehog, which controls limb growth by regulating chondrocyte proliferation and maturation (Yoshida et al. 2004).

Literature References
PubMed ID Title Journal Year
15107406 Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog

Ito, Y, Fujita, T, Komori, T, Inoue, K, Takada, K, Yoshida, CA, Furuichi, T, Yamamoto, H, Zanma, A, Ito, K, Yamana, K

Genes Dev. 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX2:CBFB:IHH gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX2:CBFB:IHH gene [nucleoplasm]
Inferred From
Ihh gene expression is stimulated by Runx2 (Mus musculus)
Authored
Orlic-Milacic, M  (2016-07-01)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-07-01)
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