Acsm3 ligates CoA to BUT

Stable Identifier
R-MMU-8875039
Type
Reaction [transition]
Species
Mus musculus
Compartment
mitochondrial matrix
ReviewStatus
5/5
General
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PNG
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Acsm3 ligates CoA to BUT
Mitochondrial acyl-coenzyme A synthetase Acsm3 (aka protein Sa) is expressed in the mitochondrial matrix and possesses medium-chain fatty acid:CoA ligase activity. Acsm3 preferentially ligates C2-C6 fatty acids, especially butyrate (BUT, a C4 fatty acid) (Fujino et al. 2001). The product, butyryl-CoA (BT-CoA) is used in beta oxidation.
Literature References
PubMed ID Title Journal Year
11470804 Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product

Sakai, J, Takei, YA, Kamataki, A, Takahashi, S, Fujino, T, Sone, H, Yamamoto, TT, Magoori, K, Ioka, RX

J Biol Chem 2001
Participants
Input
Output
Catalyst Activity

butyrate-CoA ligase activity of Acsm3 [mitochondrial matrix]

Physical Entity
Acsm3 [mitochondrial matrix] (Mus musculus)
Activity
butyrate-CoA ligase activity (GO:0047760)
Orthologous Events
ACSM3,ACSM6 ligate CoA to BUT (Homo sapiens)
Authored
Jassal, B  (2016-06-01)
Reviewed
D'Eustachio, P  (2016-07-15)
Created
Jassal, B  (2016-06-01)
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