Pnpla7 hydrolyzes LysoPtdCho

Stable Identifier
R-MMU-8847904
Type
Reaction [transition]
Species
Mus musculus
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
General
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Pnpla7 hydrolyzes LysoPtdCho
The mouse protein Pnpla7 (Patatin-like phospholipase domain-containing protein 7, also known as NRE - NTE-related esterase) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of LysoPtcCho (lysophosphatidylcholine) to GPCho (glycerophosphocholine) and LCFA (long chain fatty acid). The subcellular location of the enzyme and its specificity have been established through studies of recombinant mouse enzyme expressed in transiently transfected cells (Kienesberger et al. 2008).
Literature References
PubMed ID Title Journal Year
18086666 Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase

Kienesberger, PC, Lass, A, Preiss-Landl, K, Wolinski, H, Kohlwein, SD, Zimmermann, R, Zechner, R

J. Biol. Chem. 2008
Participants
Input
Output
Catalyst Activity

phosphatidylcholine lysophospholipase A1 activity of Pnpla7 [endoplasmic reticulum membrane]

Physical Entity
Pnpla7 [endoplasmic reticulum membrane] (Mus musculus)
Activity
phosphatidylcholine lysophospholipase A1 activity (GO:0004622)
Orthologous Events
PNPLA7 hydrolyzes LysoPtdCho (Homo sapiens)
Authored
D'Eustachio, P  (2015-12-03)
Reviewed
Jassal, B  (2015-11-30)
Created
D'Eustachio, P  (2015-12-03)
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