Reactome | Rprd2 [nucleoplasm]

Rprd2 [nucleoplasm]

Stable Identifier

R-MMU-6814906

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

RPRD2, Q6NXI6

Locations in the PathwayBrowser

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Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - RNA polymerase II transcribes snRNA genes (Mus musculus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Rprd2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Rprd2 [nucleoplasm] (Mus musculus)
    - Integrator complex processes the 3' end of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Rprd2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Rprd2 [nucleoplasm] (Mus musculus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Rprd2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Rprd2 [nucleoplasm] (Mus musculus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Rprd2 [nucleoplasm] (Mus musculus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Mus musculus)
        
        Rprd2 [nucleoplasm] (Mus musculus)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Mus musculus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Mus musculus)
        
        Rprd2 [nucleoplasm] (Mus musculus)
      - Rprd2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6NXI6

Gene Names

Rprd2

Reference Genes

BioGPS Gene:75137 Rprd2

ENSEMBL:ENSMUSG00000028106

KEGG:mmu:75137 Rprd2

Monarch:75137 Rprd2

NCBI Gene:75137 Rprd2

UCSC:Q6NXI6 Rprd2

Reference Transcript

Other Identifiers

10500237

110968_at

1431425_a_at

1431426_at

1434817_s_at

1438028_at

1438029_at

1455253_at

17407886

4328480

4356980

4363627

4373819

4417351

4478411

4511872

4602322

4722907

4738358

4754557

4761190

4774166

4793101

4841025

4864331

4931630

4941966

4943181

4958307

5010715

5028878

5031725

5054794

5075668

5184607

5188580

5209384

5282474

5397425

5421059

5436771

5443849

5459315

5506611

5586327

75137

A_51_P195935

A_52_P344354

A_52_P385465

A_52_P628618

A_52_P681918

A_55_P2039205

GE124823

GE1531102

GO:0000993

GO:0016071

GO:0031124

GO:0097550

GO:0099122

ILMN_1217909

ILMN_1244778

ILMN_3081402

mMR031120

Participates

as a component of

as an input of

RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Mus musculus)

Inferred From

RPRD2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001355108.1, NP_001074762.1

ENSEMBL

ENSMUST00000090791, ENSMUSG00000028106, ENSMUSP00000088297

PRO

Q6NXI6

GlyGen

Q6NXI6

MGI

1922387