Rora and Ep300 bind Npas2 gene

Stable Identifier
R-MMU-5663256
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Rora and Ep300 bind Npas2 gene
Rora binds the promoter of the Npas2 gene and enhances transcription (Crumbley et al. 2010). Rora binds ROR response elements (RRE, RORE) and recruits the coactivators PGC-1alpha (Ppargc1a) and p300 (Ep300, a histone acetylase) (Lau et al. 2004, Liu et al. 2007).
Literature References
PubMed ID Title Journal Year
17476214 Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism

Liu, C, Li, S, Liu, T, Borjigin, J, Lin, JD

Nature 2007
20817722 Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene

Crumbley, C, Wang, Y, Kojetin, DJ, Burris, TP

J Biol Chem 2010
15199055 RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR

Lau, P, Nixon, SJ, Parton, RG, Muscat, GE

J Biol Chem 2004
Participants
Input
Output
Orthologous Events
RORA and EP300 bind NPAS2 gene (Homo sapiens)
Authored
May, B  (2015-01-16)
Reviewed
Delaunay, F  (2012-01-28)
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2015-01-17)
Cite Us!