RORA, EP300 bind NPAS2 gene

Stable Identifier
R-HSA-5663246
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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RORA, EP300 bind NPAS2 gene
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As inferred from mouse, RORA binds RRE DNA elements and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase). As inferred from mouse, ROR-alpha binds the promoter of the NPAS2 gene and enhances transcription.

Literature References
PubMed ID Title Journal Year
24196956 Nuclear receptor-mediated cell-autonomous oscillatory expression of the circadian transcription factor, neuronal PAS domain protein 2 (NPAS2)

Matsumura, R, Matsubara, C, Node, K, Takumi, T, Akashi, M

J. Biol. Chem. 2013
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Rora, Ep300 bind Npas2 gene (Mus musculus)
Authored
May, B  (2015-01-16)
Reviewed
Delaunay, F  (2012-01-28)
Created
May, B  (2015-01-17)