Traf3ip1 binds Ift20

Stable Identifier
R-MMU-5617819
Type
Reaction [binding]
Species
Mus musculus
Compartment
cilium
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Traf3ip1 binds Ift20
Mouse Ift20 was identified as a Danio rerio Traf3ip1-binding partner by two hybrid analysis (Omori et al, 2008). Consistent with this, mouse IFT20 has been shown to bind to the C-terminal region of mouse Traf3ip3, and residues 570-625 of Traf3ip1 are sufficient both to IP Ift20 and to disrupt the Golgi localization of Ift20 (Follit et al, 2009). Traf3ip1 is postulated to bridge the 'Golgi complex' and 'IFT B' roles of Ift20, promoting vesicular traffic to the site of cilium assembly (Follit et al, 2008; Follit et al, 2009; reviewed in Ishikawa and Marshall, 2011).
Literature References
PubMed ID Title Journal Year
21427764 Ciliogenesis: building the cell's antenna

Ishikawa, H, Marshall, WF

Nat. Rev. Mol. Cell Biol. 2011
19253336 Characterization of mouse IFT complex B

Follit, JA, Xu, F, Keady, BT, Pazour, GJ

Cell Motil. Cytoskeleton 2009
19112494 The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex

Follit, JA, San Agustin, JT, Xu, F, Jonassen, JA, Samtani, R, Lo, CW, Pazour, GJ

PLoS Genet. 2008
18364699 Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8

Omori, Y, Zhao, C, Saras, A, Mukhopadhyay, S, Kim, W, Furukawa, T, Sengupta, P, Veraksa, A, Malicki, J

Nat. Cell Biol. 2008
Participants
Input
Output
Orthologous Events
TRAF3IB1 recruits IFT20 to the IFT B complex from the Golgi (Homo sapiens)
Authored
Rothfels, K  (2014-08-07)
Reviewed
Lorentzen, E  (2014-11-10)
Goncalves, J  (2014-11-14)
Created
Rothfels, K  (2014-08-14)
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