Unknown nuclease cleaves cleaved transposon RNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12

Stable Identifier
R-MMU-5606226
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Unknown nuclease cleaves cleaved transposon RNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12
After the cleaved RNA binds Piwil2 (Mili) the 3' end is trimmed by an unknown nuclease to generate a mature piRNA (De Fazio et al. 2011). The resulting Piwil2:piRNA complex can then participate in further cycles of the "ping pong cycle".
Literature References
PubMed ID Title Journal Year
22020280 The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements

De Fazio, S, Bartonicek, N, Di Giacomo, M, Abreu-Goodger, C, Sankar, A, Funaya, C, Antony, C, Moreira, PN, Enright, AJ, O'Carroll, D

Nature 2011
Participants
Input
Output
Orthologous Events
Unknown nuclease cleaves cleaved transposon RNA in 6xMeR-PIWIL2:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)
Authored
May, B  (2014-07-05)
Reviewed
Saito, K  (2014-10-25)
Created
May, B  (2014-07-07)
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