Unknown nuclease cleaves cleaved transposon RNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12

Stable Identifier
R-MMU-5606226
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Unknown nuclease cleaves cleaved transposon RNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12

After the cleaved RNA binds Piwil2 (Mili) the 3' end is trimmed by an unknown nuclease to generate a mature piRNA (De Fazio et al. 2011). The resulting Piwil2:piRNA complex can then participate in further cycles of the "ping pong cycle".

Literature References
PubMed ID Title Journal Year
22020280 The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements

De Fazio, S, Bartonicek, N, Di Giacomo, M, Abreu-Goodger, C, Sankar, A, Funaya, C, Antony, C, Moreira, PN, Enright, AJ, O'Carroll, D

Nature 2011
Participants
Orthologous Events
Authored
Reviewed
Created
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