lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [Elovl4]

Stable Identifier
R-MMU-548848
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
General
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lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [Elovl4]
Mouse elongation of very long chain fatty acids protein 4 (Elovl4) catalyzes the reaction of lignoceroyl-CoA and malonyl-CoA to form 3-oxocerotoyl-CoA, CO2, and CoASH (Agbada et al. 2008).
Literature References
PubMed ID Title Journal Year
16036915 Dominant negative mechanism underlies autosomal dominant Stargardt-like macular dystrophy linked to mutations in ELOVL4

Grayson, C, Molday, RS

J Biol Chem 2005
18728184 Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids

Agbaga, MP, Brush, RS, Mandal, MN, Henry, K, Elliott, MH, Anderson, RE

Proc Natl Acad Sci U S A 2008
Participants
Input
Output
Catalyst Activity

fatty acid elongase activity of Elovl4 [endoplasmic reticulum membrane]

Physical Entity
Elovl4 [endoplasmic reticulum membrane] (Mus musculus)
Activity
fatty acid elongase activity (GO:0009922)
Orthologous Events
ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA (Homo sapiens)
Authored
D'Eustachio, P  (2010-03-15)
Reviewed
Hill, DP  (2024-04-12)
Created
D'Eustachio, P  (2010-03-15)
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