Mmgt1,2 transport Mg2+ from cytosol to Golgi lumen

Stable Identifier
R-MMU-5336430
Type
Reaction [transition]
Species
Mus musculus
Compartment
Golgi lumen, Golgi membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Mmgt1,2 transport Mg2+ from cytosol to Golgi lumen
Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Mouse membrane magnesium transporter 1 and 2 (Mmgt1 and 2) mediates the uptake of Mg2+ across the Golgi membrane (Goytain & Quamme 2008).
Literature References
PubMed ID Title Journal Year
22119785 Defining human ERAD networks through an integrative mapping strategy

Christianson, JC, Olzmann, JA, Shaler, TA, Sowa, ME, Bennett, EJ, Richter, CM, Tyler, RE, Greenblatt, EJ, Harper, JW, Kopito, RR

Nat. Cell Biol. 2012
18057121 Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2

Goytain, A, Quamme, GA

Am. J. Physiol., Cell Physiol. 2008
Participants
Input
Output
Catalyst Activity

magnesium ion transmembrane transporter activity of Mmgt1,2 [Golgi membrane]

Physical Entity
Mmgt1,2 [Golgi membrane] (Mus musculus)
Activity
magnesium ion transmembrane transporter activity (GO:0015095)
Orthologous Events
MMGT1 transports Mg2+ from cytosol to Golgi lumen (Homo sapiens)
Authored
Jassal, B  (2014-03-03)
Reviewed
D'Eustachio, P  (2015-02-11)
Created
Jassal, B  (2014-03-03)
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