MMGT1 transports Mg2+ from cytosol to Golgi lumen

Stable Identifier
R-HSA-5336454
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Membrane magnesium transporter 1 (MMGT1) mediates the uptake of Mg2+ across the Golgi membrane. The human MMGT1 function is inferred from mouse experiments using the orthologous Mmgt1 and 2 (Goytain & Quamme 2008). MMGT1 is also found on the ER membrane as a component of the ER membrane protein complex (EMC) which functions to degrade incorrectly folded or assembled proteins by a ubiquitin- and proteasome-dependent process known as ER-associated degradation (ERAD). MMGT1 is not implicated in this function of protein quality control (Christianson et al. 2011).

Literature References
PubMed ID Title Journal Year
18057121 Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2

Goytain, A, Quamme, GA

Am. J. Physiol., Cell Physiol. 2008
22119785 Defining human ERAD networks through an integrative mapping strategy

Christianson, JC, Olzmann, JA, Shaler, TA, Sowa, ME, Bennett, EJ, Richter, CM, Tyler, RE, Greenblatt, EJ, Harper, JW, Kopito, RR

Nat. Cell Biol. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
magnesium ion transmembrane transporter activity of MMGT1 [Golgi membrane]
Physical Entity
Activity
Inferred From
Cross References
Rhea
Authored
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Created
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