Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Membrane magnesium transporter 1 (MMGT1) mediates the uptake of Mg2+ across the Golgi membrane. The human MMGT1 function is inferred from mouse experiments using the orthologous Mmgt1 and 2 (Goytain & Quamme 2008). MMGT1 is also found on the ER membrane as a component of the ER membrane protein complex (EMC) which functions to degrade incorrectly folded or assembled proteins by a ubiquitin- and proteasome-dependent process known as ER-associated degradation (ERAD). MMGT1 is not implicated in this function of protein quality control (Christianson et al. 2011).
Tyler, RE, Bennett, EJ, Christianson, JC, Kopito, RR, Greenblatt, EJ, Sowa, ME, Olzmann, JA, Harper, JW, Richter, CM, Shaler, TA
Goytain, A, Quamme, GA
magnesium ion transmembrane transporter activity of MMGT1 [Golgi membrane]
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