RanBP2 Sumoylates Top2a with Sumo1

Stable Identifier
R-MMU-5228515
Type
Reaction [transition]
Species
Mus musculus
Compartment
nuclear envelope, nucleoplasm
ReviewStatus
5/5
General
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PNG
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RanBP2 Sumoylates Top2a with Sumo1
RanBP2 sumoylates topoisomerase Top2a with Sumo1 during interphase and mitosis (Dawlaty et al. 2008). Sumoylated Top2a is observed at centromeres and sumoylation is required for proper segregation of chromosomes (Dawlaty et al. 2008).
Literature References
PubMed ID Title Journal Year
18394993 Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha

Dawlaty, MM, Malureanu, L, Jeganathan, KB, Kao, E, Sustmann, C, Tahk, S, Shuai, K, Grosschedl, R, van Deursen, JM

Cell 2008
Participants
Input
Output
Catalyst Activity

SUMO transferase activity of Ranbp2 [nuclear envelope]

Physical Entity
Ranbp2 [nuclear envelope] (Mus musculus)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
RANBP2 SUMOylates TOP2A with SUMO1 (Homo sapiens)
Authored
May, B  (2014-01-13)
Reviewed
Zhang, XD  (2015-10-04)
Created
May, B  (2014-01-14)
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