Pcsk1 hydrolyzes ProGip to Gip

Stable Identifier
R-MMU-508227
Type
Reaction [transition]
Species
Mus musculus
Compartment
secretory granule lumen
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Pcsk1 hydrolyzes ProGip to Gip
Prohormone convertase 1 (PC1/3, NEC, Psck1) cleaves Proglucose-dependent insulinotropic polypeptide adjacent to Arg43 and Arg86.
Literature References
PubMed ID Title Journal Year
16476726 Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor

Ugleholdt, R, Poulsen, ML, Holst, PJ, Irminger, JC, Orskov, C, Pedersen, J, Rosenkilde, MM, Zhu, X, Steiner, DF, Holst, JJ

J Biol Chem 2006
12145326 Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

Zhu, X, Zhou, A, Dey, A, Norrbom, C, Carroll, R, Zhang, C, Laurent, V, Lindberg, I, Ugleholdt, R, Holst, JJ, Steiner, DF

Proc Natl Acad Sci U S A 2002
Participants
Input
Output
Catalyst Activity

serine-type endopeptidase activity of Pcsk1 [secretory granule lumen]

Physical Entity
Pcsk1 [secretory granule lumen] (Mus musculus)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
PCSK1 hydrolyzes proGIP to GIP (Homo sapiens)
Authored
May, B  (2010-02-11)
Reviewed
Bloom, SR  (2010-06-25)
Created
May, B  (2010-02-11)
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